We are currently improving TOPSAN performance issues on a development site. Two of the primary features that were slowing down TOPSAN were the external real-time feeds on protein pages and advanced search options. These features have been disabled but will be back in the next TOPSAN upgrade. We are expecting to upgrade TOPSAN within the first week of February. We should only experience a brief downtime (~20min). I will be posting exact date and time of the upgrade. We are excited to bring back some of the useful features but more importantly have a more stable and responsive site! If you have any questions please contact support at topsan dot org.